Abstract Library

#996 Good Clinical Response to a Somatostatin Analog in a Patient with Metastatic Glucagonoma and Necrolytic Migratory Erythema: 5-Year Follow-Up

Introduction: Glucagonoma is a rare neuroendocrine tumor of the pancreas usually diagnosed in advanced stages or when necrolytic migratory erythema occurs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Marín L

Authors: Marín L, Gómez D, Wandurraga E,

Keywords: glucagonoma, necrolytic migratory erithema, octreotide,

#762 Long-Term Follow-Up of MEN-1 Patients with Non-Operated Small < 2 cm Non-Functional Neuroendocrine Tumor of the Pancreas (NF-PET)

Introduction: Previous investigations from the GTE demonstrated that the risk to develop metastasis and/or death was very small for MEN-1 patients with NF-PET < 2 cm. However, the follow-up was only 3.3 years for the non-operated patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Triponez F

Authors: Triponez F, Goudet P, AFCE (French Association of Endocrine Surgeons) m, GTE (French Endocrine Tumor Study Group) m,

Keywords: MEN-1, NF-PET,

#110 Slug represents an important regulator of E-cadherin expression in neuroendocrine tumor cells of the pancreas

Introduction: Neuroendocrine tumors of the pancreas form an inhomogenous group of epithelial neoplasms. They differ from other types of pancreatic cancers by showing an extended survival of patients, which is due to a mostly slow proliferation rate of the tumor. However, some of these neuroendocrine tumors are characterized by an early onset of metastases, which cannot be predicted by any available method. The epithelial to mesenchymal transition (EMT) represents a central part of cell migration and metastasis. During EMT, cells loosen their cellular contacts, leave the tissue, and become migrating single cells. One of the integral compounds of cell adhesion represents the E-cadherin adhesion module, which contains mostly E-cadherin and several catenins. A loss of this adhesion module is associated with tumor progression, migration and metastasis in many types of cancer.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: König A

Authors: König A, Reutlinger K, Ellenrieder V, Gress T, Fendrich V,

Keywords: neuroendocrine tumor of the pancreas, E-cadherin, Slug, cell adhesion,

#37 Gastric GIST with synchronous neuroendocrine tumor of the pancreas, Case Report and Literature Review

Introduction: The Gastrointestinal Stromal Tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. These are rare tumors with an incidence of 15 new cases per million per year. They often occur in individuals over the age of 40 years, without gender predominance. The clinical behavior is variable and benign tumors are the most common. They can develop anywhere in the GI tract, but are more frequent in the stomach and small intestine. The primary treatment, when located, is the surgical resection, which can be complemented with the use of imatinib. The occurrence of neuroendocrine tumors of the pancreas is rare, representing 1-5% of pancreatic cancers, and it is estimated that its incidence does not exceed 5 to one million. The tumors considered nonfunctioning (15-32% of pancreatic neuroendocrine tumors) are not associated with any syndrome, and are usually incidental. They have a slight predominance in males, and are more frequent in the 6th decade of life. Nonfunctioning tumors of islet cells are virtually all malignant tumors, and the treatment consists of surgical resection.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Tavares A

Authors: Tavares A, Ferreira A, Arruda Viveiros F, Cidade C, Maciel J,

Keywords: gastric GIST, pancreatic neuroendocrine tumor, synchronous,